Timothy Greiner, M.D.
Interests:
Post-transplant Lymphomas
HPLC Mutation Analysis
Molecular Epidemiology
cDNA Microarray Analysis
Molecular Pathology, T-cell receptor gamma gene rearrangements
Professor
Interim Director of Hematopathology
Hematopathology, Lyphomagenesis
Research:
My clinical responsibilities include the interpretation of hematopathology-related surgical specimens, bone marrow biopsies, immunohistochemistry, and molecular gene rearrangement studies by Southern blot and PCR. In molecular diagnostics, I have developed assays for T-cell receptor gamma rearrangements for diagnosing lymphoma using denaturing gradient gel electrophoresis and capillary electrophoresis. I am also interested in characterizing subtypes of T-cell lymphomas.
My research involves the study of the etiology and progression of lymphoma by examining the mutational spectra of oncogenes and tumor suppresser genes. My laboratory is currently involved in characterizing mutations in ATM, p53 and bcl-6. We are correlating mRNA expression patterns in lymphoma with patient survival, mutation status, and morphological subtypes.
The emphasis on molecular epidemiology involves the identification of EBV subtypes molecular abnormalities in posttransplant lymphoproliferative disorders. Current funding to study post-transplant lymphomas is from the Leukemia and Lymphoma Society.
Education and Training
B.A., University of Northern Iowa, 1977
M.S., University of Iowa, 1983
M.D., University of Iowa College of Medicine, 1986
Residency, University of Iowa Hospitals and Clinics, 1986-1991; Board Certification, 1991
Molecular Pathology Research Year, 1989-1990
Hematopathology Fellowship, National Cancer Institute, 1991-1993
National Activities
Society for Hematopathology Pathologist-in-Training Award, 1993
American Cancer Society Clinical Oncology Career Development Award, 1995-98
Translational Research Grant Award, Leukemia and Lymphoma Society, 2000-03
Member of ASCP, Resident In-Service Exam Committee
Member, Editorial Board, The Journal of Molecular Diagnostics, 1999-Present
Member, Editorial Board, American Journal of Clinical Pathology, 2001-Present
National Activities
Society for Hematopathology Pathologist-in-Training Award, 1993
American Cancer Society Clinical Oncology Career Development Award, 1995-98
Translational Research Grant Award, Leukemia and Lymphoma Society, 2000-03
Grantee, Mantle Cell Lymphoma Research Program, Lymphoma Research Foundation, 2003-Present.
Member, Editorial Board, The Journal of Molecular Diagnostics, 1999-Present
Member, Editorial Board, American Journal of Clinical Pathology, 2001-Present
Chair-Elect Hematopathology Division, Association for Molecular Pathology
