Prior authorization is a process used by many insurance copanies to determine if a procedure, service, or medication will be covered. Most insurance companies are now requiring prior authorization for certain genetic and molecular laboratory testing.
What to expect after submitting a request?
What to do if prior authorization is denied or testing is not a covered benefit?
Even if prior authorization is denied or an insurance policy excludes the service for your patient, the patient may still seek testing but will be responsible for the cost of testing. Please also submit the Patient Consent for Non-Covered Lab Services Form. RPS offers financial assistance for patients who meet criteria and you can reach out to our billing team to review payment options.
Common Testing Requiring Prior Authorization:
Please note this is not an all-inclusive list of tests that require prior authorization or have limited coverge. The patient's insurance company should be contacted for plan specific details.
Test Code |
Test Name |
CPT Code(s) |
UHC Molecular Test Code |
AATM |
Alpha Antitrypsin Pyrosequencing |
81332 |
56281332 |
BCRRT |
BCR ABL Qualitative |
81207 |
56281207 |
BCRQNT |
BCR ABL Quantitative p210 |
81206 |
56281206 |
BRAF |
BRAF Mutation Detection |
81210 |
56281210 |
CALRM |
Calrecticulin Exon 9 Mutations |
81219 |
56281219_CALRM |
CEBPA |
CEBPA Gene Analysis |
81218 |
CEBPA82 |
VARIES CODES |
Chromosome analysis *see our website for other sample types and their codes |
88230,88262, 88262, 88280, 88285 and 88289 |
n/a |
EWNGS |
Ewings by RT-PCR |
81401 |
56281401 |
PROTH |
Prothrombin Factor II |
81240 |
56200038A |
VARIES CODES |
FISH Analysis |
88271, 88275 |
N/A |
FLT3 |
FLT3 ITD Mutation Detection |
81245 |
56281255 |
FLTTKD |
FLT3 TKD Mutation |
81479 |
56200050 |
FRGX |
Fragile X Mutation Analysis, Modified by CE |
81243 |
56281243 |
GIP |
Gastrointestinal Pathogen Panel |
87507 |
GIP |
PCRIG |
IgH Gene Rearrangement by DNA |
81261 |
56281261 |
JK2E12 |
JAK 2 Exon 12 Seq Detection by NGS |
81479 |
56200032_JK2E12 |
JAK2 |
JAK2 Mutation Detection by NGS, Qualitative |
81479 |
56281271_JAK2 |
LEYDN |
Leiden Factor V |
81241 |
56200038B |
MSI |
Micro Satellite Instability |
81301 |
n/a |
VARIES CODES |
Microarray Analysis |
81229 |
* Molecular testing code differs depending on testing reason/sample type. See our website for specifics |
MLH1 |
MLH1 by PCR |
81288 |
MLH1M87 |
MPLM |
MPL by NGS Mutation Detection |
81479 |
56281339 |
MYD88/MYDBM |
MYD88 Gene Analysis |
81305 |
56200041 |
MYMPO/MYMPB |
Myeloid Mutation Panel |
81450 |
56200036 |
MPNBM/MPNPB |
Myeloproliferative Neoplasm by NGS |
81450 |
56200023 |
NPM1 |
NPM1 Mutation |
81310 |
56281310 |
RESPP |
Respiratory Pathogen Panel |
0202U |
n/a |
0020 |
Rhabdomyosarcoma by RT-PCR |
81401 |
56281407 |
RHD |
RHD Genotype |
81403 |
n/a |
STPP |
Solid Tumor Precision Panel |
81445 |
56200048 |
0030 |
Synovial Sarcoma by RT-PCR |
81401 |
56281408 |
TGAMA |
T Gamma Gene Rearrangement by DNA |
81342 |
56281342 |
TP53 |
TP53 Mutation Detection by NGS* |
81352 |
56281352 |
TMB |
Tumor Mutation Burden Assay |
81479 |
56200049 |
YCMD |
Y-Chromosome Micro-Deletion |
81403 |
55801005 |
* For your patients with commercial United Healthcare insurance plans, we have updated this information on the UHC Test Directory. Please make sure you utilize the updated test codes listed below when requesting prior authorization online.
If you have any questions or need assistance with prior authorizations please contact our billing department at 402-559-9480